P6532

Prostaglandin E₂

γ-irradiated, powder, BioXtra, suitable for cell culture

• Sinónimos: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE₂
• Fórmula empírica (notación de Hill): C₂₀H₃₂O₅
• Número de CAS: 363-24-6
• Peso molecular: 352.47
• Beilstein: 4709356
• Número CE: 206-656-6
• Número MDL: MFCD00077861
• Código UNSPSC: 12352209
• eCl@ss: 42020658
• ID de la sustancia en PubChem: 24898775
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• esterilidad: γ-irradiated
• Línea del producto: BioXtra
• Formulario: powder
• potencia: 0.25-100 ng/mL
• técnicas: cell culture | mammalian: suitable
• solubilidad: ethanol: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
• Clave InChI: XEYBRNLFEZDVAW-ARSRFYASSA-N
• Información sobre el gen: human ... PTGER1(5731) , PTGER2(5732) , PTGER3(5733) , PTGER4(5734) , PTGIR(5739) ; mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Descripción

Aplicación

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.

Prostaglandin E2 has been used to determine its effects on collagen gel contraction mediated by alveolar cell carcinoma cell line A549.

Acciones bioquímicas o fisiológicas

Most biologically active prostaglandin.

Most biologically active prostaglandin. PGE₂ induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE₂-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE₂ on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.

Forma física

powder -20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H360FD
• Consejos de prudencia: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges