N149

Nimodipine

• Sinónimos: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• Fórmula empírica (notación de Hill): C₂₁H₂₆N₂O₇
• Número de CAS: 66085-59-4
• Peso molecular: 418.44
• Número CE: 266-127-0
• Número MDL: MFCD00153848
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277858
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Nivel de calidad: 200
• Formulario: powder
• color: off-white to yellow
• solubilidad: methanol: 62.5 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• emisor: Bayer
• cadena SMILES: COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
• InChI: 1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
• Clave InChI: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
• Información sobre el gen: human ... ADORA3(140) , CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNG1(786) , NR3C2(4306) ; rat ... Adora1(29290) , Adora2a(25369)

Descripción

Aplicación

Nimodipine has been used:

• as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
• as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
• in the pharmacological studies for the measurement of spine voltage escape

Acciones bioquímicas o fisiológicas

Nimodipine enhances the survival of dopaminergic substantia nigra neurons.

Nimodipine is a potent L-type Ca²⁺ channel antagonist.

Características y beneficios

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Precaución

Photosensitive

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves