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Merck
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Key Documents

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L2167

Sigma-Aldrich

L-165,041

≥98% (HPLC), powder

Sinónimos:

4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy­acetic acid

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About This Item

Fórmula empírica (notación de Hill):
C22H26O7
Número de CAS:
79558-09-1
Peso molecular:
402.44
Número MDL:
MFCD04974501
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278477
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

protect from light
under inert gas

color

off-white

mp

127-128 °C (lit.)

solubilidad

DMSO: >10 mg/mL

emisor

GlaxoSmithKline

temp. de almacenamiento

2-8°C

cadena SMILES

CCCc1c(O)c(ccc1OCCCOc2ccc(OCC(O)=O)cc2)C(C)=O

InChI

1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25)

Clave InChI

HBBVCKCCQCQCTJ-UHFFFAOYSA-N

Información sobre el gen

human ... PPARD(5467)

Aplicación

L-165,041 has been used as a peroxisome proliferator-activated receptor β/δ (PPARβ/δ) ligand to study its influence on PPARβ/δ mediated postnatal myogenesis in C2C12 myoblasts.

Acciones bioquímicas o fisiológicas

L-165041 dose-dependently blocks rat vascular smooth muscle cell (VSMC) proliferation and migration by inducing the cell cycle arrest. It has the potential to treat pathological cardiovascular conditions, such as restenosis and atherosclerosis. L-165041 also effectively inhibits the progression of diabetic nephropathy. It exhibits anti-apoptosis and anti-angiogenic effects.
PPARβ (PPARδ) selective agonist.

Características y beneficios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jun-Yang Liou et al.
Arteriosclerosis, thrombosis, and vascular biology, 26(7), 1481-1487 (2006-04-29)
To determine the role of prostacyclin (PGI2) in protecting endothelial cells (ECs) from apoptosis and elucidate the protective mechanism. To evaluate the effect of PGI2 on EC survival, we treated ECs with Ad-COX1/PGIS (Ad-COPI), which augmented selectively PGI2 production or
Jui-Ting Chang et al.
BMC pharmacology & toxicology, 18(1), 67-67 (2017-10-27)
Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activated receptor-delta (PPARδ) agonists was shown in previous studies. PPARδ agonists also stimulate glucagon-like peptide-1 (GLP-1)
Jin-Hee Park et al.
Journal of cellular biochemistry, 113(6), 1947-1954 (2012-01-12)
Peroxisome proliferator-activated receptor (PPAR)δ is known to be expressed ubiquitously and involved in lipid and glucose metabolism. Recent studies have demonstrated that PPARδ is expressed in endothelial cells (ECs) and plays a potential role in endothelial survival and proliferation. Although
Romain Harmancey et al.
The Journal of biological chemistry, 290(52), 30947-30961 (2015-11-12)
The risk for heart failure and death after myocardial infarction is abnormally high in diabetic subjects. We and others have shown previously that mitochondrial uncoupling protein 3 (UCP3) improves functional recovery of the rodent heart during reperfusion. Here, we demonstrate

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