P0021

Pantoprazole sodium hydrate

≥98% (HPLC)

• Sinónimos: 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate
• Fórmula empírica (notación de Hill): C₁₆H₁₄F₂N₃O₄S · Na · xH₂O
• Número de CAS: 718635-09-7
• Peso molecular: 405.35 (anhydrous basis)
• Código UNSPSC: 12352203
• ID de la sustancia en PubChem: 329819976
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• condiciones de almacenamiento: desiccated
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• color: white to off-white
• solubilidad: H₂O: ≥20 mg/mL
• emisor: Novartis
• temp. de almacenamiento: −20°C
• cadena SMILES: O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
• InChI: 1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
• Clave InChI: CGJRLPRCWSHOFU-UHFFFAOYSA-N
• Información sobre el gen: human ... ATP4A(495) , ATP4B(496)

Descripción

Aplicación

Pantoprazole sodium hydrate has been used:

• as a standard in high-performance liquid chromatography (HPLC){58
• as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
• to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

Acciones bioquímicas o fisiológicas

Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.

Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.

Pantoprazole is a gastric proton pump inhibitor.

Características y beneficios

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable