G6649

Genistein

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

• Sinónimos: 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Fórmula empírica (notación de Hill): C₁₅H₁₀O₅
• Número de CAS: 446-72-0
• Peso molecular: 270.24
• Beilstein: 263823
• Número CE: 207-174-9
• Número MDL: MFCD00016952
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278036
• NACRES: NA.77

Propiedades

• product name: Genistein, synthetic, ≥98% (HPLC), powder
• origen biológico: synthetic
• Nivel de calidad: 200
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: off-white to yellow
• mp: 297.0-298.0 °C
• solubilidad: DMSO: soluble; ethanol: soluble
• temp. de almacenamiento: −20°C
• cadena SMILES: Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
• Clave InChI: TZBJGXHYKVUXJN-UHFFFAOYSA-N
• Información sobre el gen: human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100) ; mouse ... Esr1(13982) , Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

Descripción

Descripción general

Genistein is an isoflavonoid present among Leguminosae family of plants. It is structurally similar to estrogen (estradiol-17β).

Aplicación

Genistein has been used:

• as a test compound to access its estrogeniic acivity
• as an oestrogenic ligand to carry out identical reporter gene activation assays and also used to examine the binding of genistein to hERβ
• as an endocytosis inhibitor to test the possible effect of endocytosed advanced glycation end - bovine serum albumin (AGE-BSA) on lysosomes

Acciones bioquímicas o fisiológicas

Genistein is essential for plant-microbe interaction. It acts as a natural chemoprotectant and helps in preventing tumor progression and heart disorders. Genistein functionally shares estrogen′s action. It is useful in evaluating nutraceuticals and functional foods. Genistein exhibits antimicrobial action and can serve as a phytoalexin and phytoanticipin.

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Chloride Channels and Met pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Genistein is soluble in DMSO and ethanol. It is also soluble in chlorform:methanol (1:1 (v:v), 10 mg/ml).

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type N95 (US)