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A7410

Sigma-Aldrich

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

Sinónimos:

N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

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About This Item

Fórmula empírica (notación de Hill):
C6H8ClN7O · HCl · xH2O
Número de CAS:
2016-88-8
Peso molecular:
266.09 (anhydrous basis)
Número MDL:
MFCD03703482
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24277817
NACRES:
NA.77

product name

Amiloride hydrochloride hydrate, ≥98% (HPLC), powder

Análisis

≥98% (HPLC)

formulario

powder

color

yellow

mp

285-288 °C (dec.)

solubilidad

H2O: 50 mg/mL, clear, yellow-green

emisor

Perrigo

temp. de almacenamiento

room temp

cadena SMILES

O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2

Clave InChI

WDZJJRLYFQNCQL-UHFFFAOYSA-N

Información sobre el gen

human ... ABP1(26) , ACCN1(40) , ACCN2(41) , PLAU(5328) , SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , TNF(7124)
mouse ... Abp1(76507) , Accn1(11418) , Accn2(11419) , Plau(18792) , Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) , Slc9a1(20544)
rat ... Abp1(65029) , Accn1(25364) , Accn2(79123) , Plau(25619) , Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782)

Aplicación

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

Acciones bioquímicas o fisiológicas

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Precaución

Protect from light.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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