F9765

Filipin complex

powder, ≥70% (UV)

• Sinónimos: Filimarisin
• Número de CAS: 11078-21-0
• Número MDL: MFCD00131073
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nombre del producto: Filipin complex from Streptomyces filipinensis, ≥70% (UV)
• origen biológico: Streptomyces sp. (Streptomyces filipinensis)
• Nivel de calidad: 200
• Ensayo: ≥70% (UV)
• Formulario: powder
• solubilidad: methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow
• espectro de actividad antibiótica: fungi
• Modo de acción: cell membrane | interferes
• temp. de almacenamiento: −20°C
• InChI: 1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
• Clave InChI: IMQSIXYSKPIGPD-YQRUMEKGSA-N

Descripción

Descripción general

Chemical structure: macrolide

Aplicación

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

Acciones bioquímicas o fisiológicas

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability and associated functions via binding to membrane sterols. Filipin binds to membrane sterols such as cholesterol, and it both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Otras notas

Filipin contains 8 isomeric components, with filipin III as the major component.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable