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F5542

Sigma-Aldrich

Fibroblast Growth Factor-Acidic human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, suitable for cell culture

Sinónimos:

FGF-1, aFGF

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About This Item

Número MDL:
MFCD00081269
Código UNSPSC:
12352202
NACRES:
NA.77

product name

Fibroblast Growth Factor-Acidic human, FGF-Acidic, recombinant, expressed in E. coli, suitable for cell culture

origen biológico

human

Nivel de calidad

200

recombinante

expressed in E. coli

Análisis

≥97% (SDS-PAGE)

formulario

lyophilized powder

potencia

0.287 ng/mL

calidad

endotoxin tested

mol peso

15.5 kDa

envase

pkg of 25 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell culture | mammalian: suitable

impurezas

≤1.0 EU/mg (LAL test)

Nº de acceso UniProt

P05230

temp. de almacenamiento

−20°C

Información sobre el gen

human ... FGF1(2246)

Categorías relacionadas

Descripción general

Fibroblast Growth Factor-Acidic (FGF1) belongs to the FGF family and comprises a nuclear export sequence (NES). FGF1 gene is mapped to human chromosome 5q31.3. FGF1 is highly expressed in the central and peripheral nervous system.

Aplicación

Fibroblast Growth Factor-Acidic human has been used:
  • as a component of growth factor cocktail for treating neural stem cell (NSC) transplants
  • as a component of Human Neural Stem Cell (HNSC) proliferation medium for Neural Tissue Spheres (NTS) propagation
  • as a growth factor component in fibrin matrix to support embryonic day 14 (E14) cells graft survival

Acciones bioquímicas o fisiológicas

Fibroblast Growth Factor-Acidic (FGF1) is a potent mitogenic agent associated with a variety of tissue origins including liver, vasculature, and skin. These include for a wide variety of mesoderm-derived cells including BALB/c 3T3 fibroblasts, capillary and endocardial endothelial cells, myoblasts, vascular smooth muscle cells, mesothelial cells, glial and astroglial cells, and adrenal cortex. FGF1 participates in glucose homeostasis, adipose tissue remodeling and is a key transducer of the nuclear receptor, peroxisome proliferator-activated receptor γ (PPARγ). FGF1 is a neuronal cell neurotrophic factor and binds to most of the isoforms of the FGF receptor (FGFR) isoforms. Along with FGF2, FGF1 plays a key role in angiogenesis and favors blood vessel formation in chronic inflammatory diseases and cancer. The FGF1 mutant R50E leads to suppression of its angiogenic potential making it a potential anti-angiogenesis agent.

Forma física

The product is lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 1 M NaCl, 5 mM DTT containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Nota de análisis

The proliferative activity is tested in culture using quiescent NR6R-3T3 fibroblasts.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Paul Lu et al.
Cell, 150(6), 1264-1273 (2012-09-18)
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multiple cellular phenotypes, including neurons, which extended large numbers of axons over
T Yamashita et al.
Biochemical and biophysical research communications, 277(2), 494-498 (2000-10-18)
We isolated mouse cDNA encoding a novel FGF (251 amino acids). As this is the 23rd documented FGF, we termed it FGF-23. FGF-23 has a hydrophobic amino terminus ( approximately 24 amino acids), which is a typical signal sequence. As
Zhifeng Huang et al.
Cell reports, 20(7), 1717-1728 (2017-08-17)
The recent discovery of metabolic roles for fibroblast growth factor 1 (FGF1) in glucose homeostasis has expanded the functions of this classically known mitogen. To dissect the molecular basis for this functional pleiotropy, we engineered an FGF1 partial agonist carrying triple
A Rizzino et al.
Cancer research, 48(15), 4266-4271 (1988-08-01)
The work described in this paper demonstrates that the cellular binding of transforming growth factor beta, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor is reduced as cell density is increased. The reduction in transforming growth factor beta
Brian V Lien et al.
Experimental neurology, 314, 46-57 (2019-01-18)
Neural stem cells (NSCs) can differentiate into both neurons and glia after transplantation into spinal cord injury (SCI) sites. The neuronal component of stem cell grafts has the potential to form functional synaptic relays across the lesion site. The glial
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