C8999

Calpeptin

≥98% (HPLC)

• Sinónimos: N-Benzyloxycarbonyl-L-leucylnorieucinal, Z-Leu-Nle-CHO
• Fórmula empírica (notación de Hill): C₂₀H₃₀N₂O₄
• Número de CAS: 117591-20-5
• Peso molecular: 362.46
• Número MDL: MFCD00155623
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329775192
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 15 mg/mL, clear
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
• InChI: 1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1
• Clave InChI: PGGUOGKHUUUWAF-ROUUACIJSA-N

Descripción

Descripción general

Calpeptin (Z-Leu-nLeu-H) is a cell permeable, peptide aldehyde inhibitor. It is more sensitive to calpain I compared to other inhibitors, such as Z-Leu-Met-H and leupeptin. Calpeptin stimulates neurite elongation in differentiating pheochromocytoma (PC12) cells. Calpeptin decreases microgliosis, astrogliosis, axonal damage and neuron and oligodendrocyte death in experimental autoimmune encephalomyelitis (EAE) spinal cord. Therefore, it can be considered as a potent therapeutic for treating EAE and multiple sclerosis (MS).

Aplicación

Calpeptin has been used as a calpain inhibitor.

Acciones bioquímicas o fisiológicas

Calpeptin is a rho kinase activator and an inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in apoptosis, long-term potentiation in neurons, and cell cycle progression.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable