C7291

Clomipramine hydrochloride

≥98% (HPLC), powder

• Sinónimos: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
• Fórmula empírica (notación de Hill): C₁₉H₂₃ClN₂ · HCl
• Número de CAS: 17321-77-6
• Peso molecular: 351.31
• Número CE: 241-344-3
• Número MDL: MFCD00069234
• Código UNSPSC: 12352116
• ID de la sustancia en PubChem: 24278087
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to off-white
• solubilidad: H₂O: 25 mg/mL; 0.1 M HCl: soluble
• emisor: Novartis
• cadena SMILES: Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
• InChI: 1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
• Clave InChI: WIMWMKZEIBHDTH-UHFFFAOYSA-N
• Información sobre el gen: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Descripción

Descripción general

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

Aplicación

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.

Clomipramine hydrochloride has been used:

• to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
• to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
• as a serotonin reuptake inhibitor
• as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

Acciones bioquímicas o fisiológicas

Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

Características y beneficios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08,GHS07,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H302,H336,H370,H410
• Consejos de prudencia: P260 - P264 - P271 - P273 - P301 + P312 - P308 + P311
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
• Órganos de actuación: Central nervous system, Central nervous system,Cardiovascular
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves