A1527
Adrenocorticotropic Hormone Fragment 7-38 human
≥97% (HPLC)
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About This Item
Fórmula empírica (notación de Hill):
C167H257N47O46
Número de CAS:
Peso molecular:
3659.11
Número MDL:
Código UNSPSC:
51111800
Productos recomendados
esterilidad
non-sterile
Nivel de calidad
Análisis
≥97% (HPLC)
formulario
powder
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... POMC(5443)
Categorías relacionadas
Amino Acid Sequence
Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu
Aplicación
Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.
Acciones bioquímicas o fisiológicas
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.
Otras notas
ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Lyophilized from 0.1% TFA in H2O
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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