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Documentos clave

A1527

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 7-38 human

≥97% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C167H257N47O46
Número de CAS:
68563-24-6
Peso molecular:
3659.11
Número MDL:
MFCD00081282
Código UNSPSC:
51111800

esterilidad

non-sterile

Nivel de calidad

200

Ensayo

≥97% (HPLC)

Formulario

powder

Nº de acceso UniProt

P01189

temp. de almacenamiento

−20°C

Información sobre el gen

human ... POMC(5443)

Categorías relacionadas

Amino Acid Sequence

Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu

Aplicación

Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.

Acciones bioquímicas o fisiológicas

Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.

Otras notas

ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Lyophilized from 0.1% TFA in H2O

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
109M4787V
069M4773V
029M4876V
078M4781V
078M4782V

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Juan Castillo et al.
The Journal of endocrinology, 196(2), 313-322 (2008-02-07)
Steroidogenic acute regulatory protein (StAR) transfers cholesterol over the inner mitochondrial membrane. In mammals, StAR controls this rate-limiting step of steroidogenesis, but its expression and regulation has not been well explored in fish. The present work investigates StAR mRNA expression
V L Clifton et al.
The Journal of clinical endocrinology and metabolism, 81(4), 1406-1410 (1996-04-01)
During human pregnancy, ACTH is produced by both the placenta and fetal pituitary. ACTH has been shown to cause vasodilatation in the adrenal cortex in vitro. In this context we have investigated the vasoactive effects of ACTH in the human
Kristin L Schreiber et al.
Stress (Amsterdam, Netherlands), 8(3), 185-190 (2005-12-06)
Exposure to stress is associated with susceptibility to disease and one stress mediator, norepinephrine, has been reported to enhance the adherence of enterohemorrhagic Escherichia coli O157:H7 (EHEC) to the colonic mucosa. We tested the hypothesis that adrenocorticotropic hormone (ACTH) and
L K Malendowicz et al.
The Journal of steroid biochemistry and molecular biology, 67(2), 149-152 (1999-01-07)
Corticotropin-inhibiting peptide (CIP), the 7-38 fragment of human ACTH(1-39), is known to act as an antagonist of ACTH receptors. Accordingly, CIP has been found to inhibit ACTH-stimulated glucocorticoid secretion of dispersed rat adrenocortical cells, without per se affecting the basal
L K Malendowicz et al.
The Journal of steroid biochemistry and molecular biology, 70(4-6), 185-188 (2000-01-06)
Orexins-A and B are two novel hypothalamic peptides, which, like leptin and neuropeptide-Y (NPY), are involved in the central regulation of feeding. Since leptin and NPY were found to modulate adrenal function, we have examined whether orexins are able to
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