A9650

Angiotensin I human acetate salt hydrate

≥90% (HPLC), powder, suitable for mammalian cell culture

• Sinónimos: 5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I
• Fórmula empírica (notación de Hill): C₆₂H₈₉N₁₇O₁₄ · xC₂H₄O₂ · yH₂O
• Número de CAS: 70937-97-2
• Peso molecular: 1296.48 (anhydrous free base basis)
• Número MDL: MFCD00133091
• Código UNSPSC: 12352202
• eCl@ss: 42020611
• ID de la sustancia en PubChem: 24891483
• NACRES: NA.32

Propiedades

• origen biológico: human
• Nivel de calidad: 200
• Análisis: ≥90% (HPLC)
• formulario: powder
• mol peso: 1296 Da by calculation (Average Mass)
• condiciones de almacenamiento: (Keep container tightly closed in a dry and well-ventilated place)
• técnicas: cell culture | mammalian: suitable
• solubilidad: acetic acid: 25 mg/mL, clear, colorless
• Nº de acceso UniProt: P01019
• temp. de almacenamiento: −20°C
• cadena SMILES: CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O
• InChI: 1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1
• Clave InChI: CKIFOTYDIFUKEP-AUVUXLIHSA-N
• Información sobre el gen: human ... AGT(183)

Descripción

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

Descripción general

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Research area: Cell Signaling

Aplicación

Angiotensin I human acetate salt hydrate has been used:

• as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
• to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
• as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

Acciones bioquímicas o fisiológicas

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.

Adsorbente de anticuerpos

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH₃COOH.6H₂O

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)