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F3261

Sigma-Aldrich

[Glu1]-Fibrinopeptide B human

≥90% (HPLC)

Sinónimos:

Fibrinopeptide B

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About This Item

Fórmula empírica (notación de Hill):
C66H95N19O26
Número de CAS:
103213-49-6
Peso molecular:
1570.57
Número MDL:
MFCD00076440
Código UNSPSC:
12352202
ID de la sustancia en PubChem:
329799697
NACRES:
NA.32

origen biológico

human

Nivel de calidad

200

Análisis

≥90% (HPLC)

formulario

powder

técnicas

LC/MS: suitable
electrophoresis: suitable

Nº de acceso UniProt

P02675

temp. de almacenamiento

−20°C

cadena SMILES

CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C66H95N19O26/c1-31(2)53(85-48(90)29-73-55(100)35(67)16-19-49(91)92)64(109)83-42(26-46(69)88)61(106)82-43(27-52(97)98)62(107)81-41(25-45(68)87)60(105)78-37(18-21-51(95)96)57(102)77-36(17-20-50(93)94)56(101)74-28-47(89)76-39(23-33-11-6-4-7-12-33)58(103)80-40(24-34-13-8-5-9-14-34)59(104)84-44(30-86)63(108)75-32(3)54(99)79-38(65(110)111)15-10-22-72-66(70)71/h4-9,11-14,31-32,35-44,53,86H,10,15-30,67H2,1-3H3,(H2,68,87)(H2,69,88)(H,73,100)(H,74,101)(H,75,108)(H,76,89)(H,77,102)(H,78,105)(H,79,99)(H,80,103)(H,81,107)(H,82,106)(H,83,109)(H,84,104)(H,85,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)(H4,70,71,72)/t32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1

Clave InChI

KPBJTGOVJLITON-OECXYHNASA-N

Información sobre el gen

human ... FGB(2244)

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Amino Acid Sequence

Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg

Descripción general

Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain. This peptide is composed of 14 amino acids.

Aplicación

[Glu1]-Fibrinopeptide B human has been used:
  • during LC-MS to avoid cross-contamination and to analyze the performance of mass spectrometer and LC-instrument
  • for two-point calibration during 2D (dimensional) gel electrophoresis and protein identification by mass spectrometry of histidine (his)-Pup (prokaryotic ubiquitin-like protein) isolated from Mycobacterium smegmatis
  • for two-point calibration during one-dimensional gel electrophoresis and tandem mass spectrometry (MS) for the characterization of soluble protein sample obtained from the salivary gland homogenates of Cimex lectularius
  • as a standard for the correction of mass drift in data obtained from MS and MS/MS performed on peptides obtained from trypsin-digestion of protein disulfide isomerase (PDI)

Acciones bioquímicas o fisiológicas

Fibrin formation is an essential part in wound healing and inflammation. Fibrinopeptide B (FPB) can also cause chemotactic migration of neutrophils, without the simultaneous release of lysosome enzymes. It is produced during the coagulation of fibrinogen, which is essential for physiological homeostasis. It is involved in various disorders such as thrombosis and disseminated intravascular coagulation.

Otras notas

Lyophilized from 0.1% TFA in H2O

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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