73914

Sphingosine 1-phosphate

≥98.0% (TLC)

• Sinónimos: (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate, D-erythro-Sphingosine 1-phosphate
• Fórmula empírica (notación de Hill): C₁₈H₃₈NO₅P
• Número de CAS: 26993-30-6
• Peso molecular: 379.47
• Número MDL: MFCD00270077
• Código UNSPSC: 12352211
• ID de la sustancia en PubChem: 329765332
• NACRES: NA.85

Propiedades

• Análisis: ≥98.0% (TLC)
• formulario: powder
• composición: carbon content, 56.97% ; hydrogen content, 10.09% ; nitrogen content, 3.69%
• tipo de lípido: sphingolipids
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
• InChI: 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
• Clave InChI: DUYSYHSSBDVJSM-KRWOKUGFSA-N

Descripción

Aplicación

Repurposing Siponimod for osteoporosis: A study highlighted the potential of Siponimod, an S1P receptor modulator originally developed for multiple sclerosis, to treat osteoporosis by influencing Sphingosine 1-phosphate pathways (Hu et al., 2024).

Sphingosine-1-phosphate in ocular health: Research demonstrated that a selective agonist for Sphingosine-1-phosphate receptor 1/5 could mitigate ocular vascular pathologies, suggesting therapeutic potentials in eye disease management, it is also responsible for regulating various intracellular processes, including cell survival, differentiation, and proliferation (Nakamura et al., 2024).

Targeting diabetic kidney disease: The study investigated how Plantaginis Semen, through the sphingosine kinase 1/Sphingosine-1-phosphate pathway, could ameliorate diabetic kidney disease, underscoring the pathways role in metabolic health (Lan et al., 2024).

Advancements in neurodegenerative disease treatments: A review focused on the development of small-molecule modulators targeting Sphingosine-1-phosphate receptors, presenting new directions in treating neurodegenerative diseases (Sankar Kar et al., 2024).

Acciones bioquímicas o fisiológicas

A lipid second messenger that binds to S1P₁ and S1P₃ receptors. Mobilizes intracellular Ca²⁺ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable