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Merck

PHR1691

Supelco

4-Epianhydrotetracycline hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

4-Epianhydrotetracycline hydrochloride, (4R,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide monohydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C22H22N2O7 · HCl
Número de CAS:
Peso molecular:
462.88
Beilstein:
3840711
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to Ph. Eur. E0400000
traceable to USP 1236506

familia API

chlortetracycline, tetracycline

CofA

current certificate can be downloaded

envase

pkg of 500 mg

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

Cl[H].[H][C@@]12Cc3c(C)c4cccc(O)c4c(O)c3C(=O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]2N(C)C

InChI

1S/C22H22N2O7.ClH/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28;/h4-6,11,16,25-27,31H,7H2,1-3H3,(H2,23,30);1H/t11-,16+,22-;/m0./s1

Clave InChI

XBSQEFHDCDFNJU-MOMXNFOMSA-N

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Descripción general

4-Epianhydrotetracycline hydrochloride is a degradation product of tetracyclines which are used as veterinary medicines.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

4-Epianhydrotetracycline hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in commercial bulk and pharmaceutical products by high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA6863 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3


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Visite la Librería de documentos

4-Epianhydrotetracycline
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 6636-6636 (2013)
A high performance liquid chromatographic system for the analysis of tetracycline drug standards, analogs, degradation products and other impurities
Mack GD and Ashworth RB
Journal of Chromatographic Science, 16(3), 93-101 (1978)
Emad M Hussien
Biomedical chromatography : BMC, 28(9), 1278-1283 (2014-03-13)
A novel reversed-phase HPLC method was developed and validated for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline hydrochloride impurity in tetracycline hydrochloride commercial bulk and pharmaceutical products. The method employed L1 (3 µm, 150 × 4.6 mm) columns, a mobile phase

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