1651009

Tetracycline hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Fórmula empírica (notación de Hill): C₂₂H₂₄N₂O₈ · HCl
• Número de CAS: 64-75-5
• Peso molecular: 480.90
• Beilstein: 3844873
• Número MDL: MFCD00078142
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329751256
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: tetracycline
• fabricante / nombre comercial: USP
• mp: 220-223 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
• Clave InChI: XMEVHPAGJVLHIG-FMZCEJRJSA-N

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Tetracycline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Tetracycline Hydrochloride Ointment
• Tetracycline Hydrochloride Capsules
• Tetracycline Hydrochloride Tablets
• Tetracycline Hydrochloride Ophthalmic Ointment
• Tetracycline Hydrochloride Soluble Powder
• Tetracycline Hydrochloride and Novobiocin Sodium Tablets

Acciones bioquímicas o fisiológicas

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS08,GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335,H361fd,H410
• Consejos de prudencia: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable