PHR1659

5-Fluorocytosine

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: 5-Fluorocytosine, 4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine
• Fórmula empírica (notación de Hill): C₄H₄FN₃O
• Número de CAS: 2022-85-7
• Peso molecular: 129.09
• Beilstein: 127285
• Número CE: 217-968-7
• Número MDL: MFCD00006035
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823537
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to Ph. Eur. F0175000; traceable to USP 1272000
• familia API: flucytosine
• CofA: current certificate can be downloaded
• envase: pkg of 1 g
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 298-300 °C (dec.) (lit.)
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: NC1=NC(=O)NC=C1F
• InChI: 1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
• Clave InChI: XRECTZIEBJDKEO-UHFFFAOYSA-N

Descripción

Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flucytosine is an antimycotic drug that can be effectively utilized against severe Candida and Cryptococcus infections.

Aplicación

Flucytosine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA5760 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Warning
• Frases de peligro: H361
• Consejos de prudencia: P281
• Clasificaciones de peligro: Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable