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Merck

PHR1307

Supelco

Captopril

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline

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About This Item

Fórmula empírica (notación de Hill):
C9H15NO3S
Número de CAS:
Peso molecular:
217.29
Beilstein:
477887
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to BP 538
traceable to Ph. Eur. C0430000
traceable to USP 1091200

familia API

captopril

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

104-108 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

Clave InChI

FAKRSMQSSFJEIM-RQJHMYQMSA-N

Información sobre el gen

human ... ACE(1636)

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Captopril acts by inhibiting the angiotensin-converting enzyme and is known as an antihypertensive agent. It finds wide use in the treatment of congestive heart failure.

Aplicación

Captopril may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA0067 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Muta. 2 - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Visite la Librería de documentos

Potentiometric determination of captopril in pharmaceutical formulations
Ribeiro PRDS, et al.
Ecletica Quimica, 28(1), 39-44 (2003)
Square-wave voltammetric (SWV) determination of Captopril in reconstituted serum and pharmaceutical formulations
Parham H and Zargar B
Talanta, 65(3), 776-780 (2005)
Validation of simultaneous volumetric and spectrophotometric methods for the determination of captopril in pharmaceutical formulations
Rahman N, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(6-7), 569-574 (2005)
Determination of captopril and its degradation products by capillary electrophoresis
Hillaert S and Van den Bossche W
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 65-73 (1999)
Analysis of captopril and hydrochlorothiazide combination tablet formulations by liquid chromatography
Kirschbaum J and Perlman S
Journal of Pharmaceutical Sciences, 73(5), 686-687 (1984)

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