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Merck

PHR1602

Supelco

Losartan Potassium

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt

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About This Item

Fórmula empírica (notación de Hill):
C22H22ClKN6O
Número de CAS:
Peso molecular:
461.00
Beilstein:
5845770
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to BP 867
traceable to Ph. Eur. Y0001062
traceable to USP 1370462

familia API

losartan

CofA

current certificate can be downloaded

envase

pkg of 1 g

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]

InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

Clave InChI

OXCMYAYHXIHQOA-UHFFFAOYSA-N

Información sobre el gen

human ... AGTR1(185)

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Losartan Potassium is a novel class of orally active, non-peptide angiotensin II (type AT1) receptor antagonist drug that can be used in the remedy of hypertension. It exhibits superior activity than many other peptide receptor antagonist drugs and angiotensin converting enzyme (ACE) inhibitors owing to the high specificity, selectivity, and tolerability.

Aplicación

Losartan Potassium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0141 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

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Visite la Librería de documentos

Validated RP-HPLC method for simultaneous quantitation of losartan potassium and metolazone in bulk drug and formulation.
Dubey R, et al.
Scientia Pharmaceutica, 79(3), 545-554 (2011)
Development and validation of a stability-indicating HPLC method for the simultaneous determination of Losartan potassium, hydrochlorothiazide, and their degradation products.
Hertzog DL, et al.
Journal of Pharmaceutical and Biomedical Analysis, 30(3), 747-760 (2002)
Spectrophotometric and HPLC methods for simultaneous estimation of amlodipine besilate, losartan potassium and hydrochlorothiazide in tablets.
Wankhede SB, et al.
Indian Journal of Pharmaceutical Sciences, 72(1), 136-136 (2010)
H Salmenkari et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 69(4) (2018-11-12)
The renin-angiotensin system (RAS) in the intestine is involved in the regulation of inflammation, apoptosis and tissue fibrosis in experimental models of colitis; the inhibition of local RAS by pharmacologic interventions has been claimed to prevent and alleviate colitis. In

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