CC115

Chicken Tenascin

from embryonic chicken brains, liquid, 0.755 mg/mL, suitable for cell culture

• Sinónimos: Cytotactin, Tenascin-C
• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.75

Propiedades

• Nombre del producto: Chicken Tenascin,
• origen biológico: chicken
• Nivel de calidad: 100
• Formulario: liquid
• mol peso: large molecular weight polypeptide 190 kDa; large molecular weight polypeptide 200 kDa; large molecular weight polypeptide 220 kDa
• fabricante / nombre comercial: Chemicon^®
• concentración: 0.755 mg/mL
• técnicas: cell culture | mammalian: suitable
• entrada: sample type hematopoietic stem cell(s); sample type mesenchymal stem cell(s); sample type pancreatic stem cell(s); sample type induced pluripotent stem cell(s); sample type neural stem cell(s); sample type epithelial cells; sample type: mouse embryonic stem cell(s)
• Nº de acceso UniProt: Q90W79
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: chicken ... CNTN5(395317)

Descripción

Descripción general

Tenascin is a large glycoprotein that forms disulfide-linked hexamers. It is made up of repeated structural domains including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Splice variants of tenascin differ in their number of fibronectin type III repeats. Tenascin is expressed in distinctive spatial and temporal patterns in most embryonic tissues at sites of tissue remodeling and cell migration. There is little expression of tenascin in adult tissues except, again, at sites of tissue remodeling and cell migration such as surrounding tumors, in healing wounds, and in branching or damaged blood vessels. Tenascin binds to several cell-surface receptors and mediates cell-substrate adhesion. Nevertheless, tenascin is frequently referred to as an anti-adhesion molecule because for a variety of cell types the presence of tenascin inhibits adhesion to other ECM proteins present. This effect occurs because the binding of tenascin to certain receptors inhibits cell spreading and thereby blocks the stabilization of adhesion that results from cell preading in vitro assays.

Forma física

Provided as a liquid in PBS, containing no preservatives.

Almacenamiento y estabilidad

Store at -20°C for up to 12 months. Avoid repeated freeze/thaw.

Nota de análisis

Isolated from embryonic chicken brains by chromatographic methods. Contains three characteristic polypeptide chains (220, 200, and 190 kDa) that migrate on SDS gels as a high molecular weight multimer under non-reducing conditions.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable