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ABN88

Sigma-Aldrich

Anti-phospho-NR1 (Ser896) Antibody

from rabbit, purified by affinity chromatography

Sinónimos:

glutamate receptor, ionotropic, N-methyl D-aspartate 1, glutamate [NMDA] receptor subunit zeta 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
clon:
polyclonal
application:
IHC
WB
reactividad de especies:
rat
técnicas:
immunohistochemistry: suitable (paraffin)
western blot: suitable
citations:
8

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

purificado por

affinity chromatography

reactividad de especies

rat

reactividad de especies (predicha por homología)

mouse (based on 100% sequence homology), human (based on 100% sequence homology)

técnicas

immunohistochemistry: suitable (paraffin)
western blot: suitable

Nº de acceso NCBI

NP_058706

Nº de acceso UniProt

P35439

Condiciones de envío

wet ice

modificación del objetivo postraduccional

phosphorylation (pSer896)

Información sobre el gen

human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)

Descripción general

NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.

Especificidad

This antibody recognizes NR1 when phosphorylated at Ser896.

Inmunógeno

Epitope: Phosphorylated Ser896
KLH-conjugated linear peptide corresponding to rat NR1 phosphorylated at Ser896.

Aplicación

Detect phospho-NR1 (Ser896) using this Anti-phospho-NR1 (Ser896) Antibody validated for use in WB, IH(P).
Immunohistochemistry Analysis: 1:25 dilution from a previous lot detected NR1 in normal rat hippocampus tissue.

Calidad

Evaluated by Western Blot in lambda phosphatase untreated and treated rat microsomal brain tissue lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected NR1 on 10 µg of lambda phosphatase untreated and treated rat microsomal brain tissue lysates.

Descripción de destino

~130kDa observed

Ligadura / enlace

Replaces: 06-640

Nota de análisis

Control
Lambda phosphatase untreated and treated rat microsomal brain tissue lysates

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Código de clase de almacenamiento

10-13 - German Storage Class 10 to 13

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jing-Dun Xie et al.
The Journal of biological chemistry, 291(37), 19364-19373 (2016-07-28)
Painful peripheral neuropathy is a severe adverse effect of chemotherapeutic drugs such as paclitaxel (Taxol). The glutamate N-methyl-d-aspartate receptors (NMDARs) are critically involved in the synaptic plasticity associated with neuropathic pain. However, paclitaxel treatment does not alter the postsynaptic NMDAR
Milena De Felice et al.
Molecular pain, 12 (2016-04-21)
Bone metastases occur frequently in advanced breast, lung, and prostate cancer, with approximately 70% of patients affected. Pain is a major symptom of bone metastases, and current treatments may be inadequate or have unacceptable side effects. The mechanisms that drive
Sheu-Ran Choi et al.
Experimental neurobiology, 28(4), 516-528 (2019-09-09)
We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory mechanisms responsible for the expression of the DHEA-synthesizing enzyme, cytochrome
Sheu-Ran Choi et al.
Biological & pharmaceutical bulletin, 39(12), 1922-1931 (2016-09-08)
We recently demonstrated that activation of spinal sigma-1 receptors (Sig-1Rs) induces pain hypersensitivity via the activation of neuronal nitric oxide synthase (nNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2). However, the potential direct interaction between nNOS-derived nitric oxide
Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G??A ALS mice: overlapping effects or limited therapeutic opportunity?
Mancuso, R; Del Valle, J; Morell, M; Pallas, M; Osta, R; Navarro, X
Orphanet Journal of Rare Diseases null
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