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AB5482

Sigma-Aldrich

Anti-Superoxide Dismutase 1 Antibody

serum, Chemicon®

Sinónimos:

SOD1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

serum

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies

rat, mouse

no debe reaccionar con

human

fabricante / nombre comercial

Chemicon®

técnicas

western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... SOD1(6647)

Descripción general

Mutations in the copper/ zinc superoxide dismutase (SOD1) gene are associated with 15- 20% of the familial forms of motoneuron disease. This 153 amino acid metalloenzyme is expressed in virtually all cells of all organisms above bacteria and is highly conserved across species, although some minor variations do occur. The incorporation of the mutated form of the SOD1 human gene into a transgenic mouse leads to the onset of the disease that closely resembles the human condition. These animals become weak at about 2-4 months of age and rapidly lose function, which results in death 4- 6 weeks later.

Especificidad

Superoxide Dismutase 1 (SOD1), mouse and rat specific. No reactivity with human SOD1

Inmunógeno

Synthetic peptide corresponding to amino acids 25-37 of mouse SOD1.

Aplicación

Detect Superoxide Dismutase 1 using this Anti-Superoxide Dismutase 1 Antibody validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress
Western blotting: 1:200-1:500 (see images)

Optimal working dilutions must be determined by end user.

Forma física

Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile water.

Almacenamiento y estabilidad

Maintain lyophilized material at -70°C (dry) for up to 12 months after date of receipt. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.
Raoul, C; Abbas-Terki, T; Bensadoun, JC; Guillot, S; Haase, G; Szulc, J; Henderson, CE; Aebischer, P
Nature Medicine null
Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice.
Carrasco, DI; Bichler, EK; Seburn, KL; Pinter, MJ
Testing null
S E Bartlett et al.
Journal of neuroscience methods, 98(1), 63-67 (2000-06-06)
Mutations in the copper/zinc superoxide dismutase (SOD1) gene are associated with 15-20% of the familial forms of motor neuron disease. Mice where a transgene has been incorporated that encodes for the human SOD1 mutation develop a form of motor neurone
Qian Wang et al.
PloS one, 7(5), e36818-e36818 (2012-05-19)
Hepatitis B virus (HBV) is a major etiological factor of hepatocellular carcinoma (HCC). However, the precise pathogenetic mechanisms linking HBV infection and HCC remain uncertain. It has been reported that decreased antioxidant enzyme activities are associated with severe liver injury

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