AB3637
Anti-DEDAF Antibody
Chemicon®, from rabbit
Sinónimos:
Anti-AAP1, Anti-APAP-1, Anti-DEDAF, Anti-YEAF1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
affinity purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
polyclonal
reactividad de especies
human, rat, mouse
fabricante / nombre comercial
Chemicon®
técnicas
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... RYBP(23429)
Especificidad
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. DEDAF (DED Associated Factor) is expressed in multiple tissues and cell lines. DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/Caspase-8 complexes at the cell membrane. DEDAF also interacts with DEDD (DED-containing DNA binding) protein in the nucleus, which indicates its involvement in the regulation of both cytoplasmic and nuclear events of apoptosis.
Inmunógeno
Rabbit anti-DEDAF polyclonal antibody was raised against a synthetic peptide corresponding to amino acids 215 to 228 of human-DEDAF. This sequence is identical to the mouse sequence.
Aplicación
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
This Anti-DEDAF Antibody is validated for use in WB for the detection of DEDAF.
Western blot: 0.5-1 μg/mL.
A549 or HepG2 cell lysate can be used as a positive control and a 32 kDa band should be detected.
Optimal working dilutions must be determined by end user.
A549 or HepG2 cell lysate can be used as a positive control and a 32 kDa band should be detected.
Optimal working dilutions must be determined by end user.
Forma física
Format: Purified
Purified IgG by immunoaffinity chromatography. Liquid in PBS containing 0.02% sodium azide.
Almacenamiento y estabilidad
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Rybp/DEDAF is required for early postimplantation and for central nervous system development.
Pirity, MK; Locker, J; Schreiber-Agus, N
Molecular and cellular biology null
Izabella Bajusz et al.
Genes, 10(11) (2019-11-23)
Separation of germline cells from somatic lineages is one of the earliest decisions of embryogenesis. Genes expressed in germline cells include apoptotic and meiotic factors, which are not transcribed in the soma normally, but a number of testis-specific genes are
Nathan R Rose et al.
eLife, 5 (2016-10-06)
Polycomb group (PcG) proteins function as chromatin-based transcriptional repressors that are essential for normal gene regulation during development. However, how these systems function to achieve transcriptional regulation remains very poorly understood. Here, we discover that the histone H2AK119 E3 ubiquitin
Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes.
Eskeland, R; Freyer, E; Leeb, M; Wutz, A; Bickmore, WA
Cold Spring Harbor Symposia on Quantitative Biology null
E García et al.
The EMBO journal, 18(12), 3404-3418 (1999-06-16)
The products of the Polycomb group (PcG) of genes are necessary for the maintenance of transcriptional repression of a number of important developmental genes, including the homeotic genes. A two-hybrid screen was used to search for putative new members of
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