520219

PPACK II trifluoroacetate salt

≥95% (HPLC), solid, kallikrein inhibitor, Calbiochem^®

• Sinónimos: PPACK II, Trifluoroacetate Salt
• Fórmula empírica (notación de Hill): C₂₅H₃₃ClN₆O₃ · 2C₂HF₃O₂
• Número de CAS: 74392-49-7
• Peso molecular: 729.07
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: PPACK II, Trifluoroacetate Salt, Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated
• color: off-white
• solubilidad: water: 100 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-21(15-18-10-5-2-6-11-18)24(35)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21,31H,7,12-16,27H2,(H4,28,29,30)(H,32,34,35)/t19-,20+,21+/m1/s1
• Clave InChI: UFXAQJOOAQICNE-HKBOAZHASA-N

Descripción

Descripción general

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H₂O (Cat. No. 508573).

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Plasma and glandular kallikreins

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-D-Phe-Phe-Arg-chloromethylketone, 2TFA

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Otras notas

Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable