520222

PPACK dihydrochloride

≥80% (HPLC), solid, thrombin inhibitor, Calbiochem^®

• Sinónimos: PPACK, Dihydrochloride
• Fórmula empírica (notación de Hill): C₂₁H₃₁ClN₆O₃ · 2HCl
• Peso molecular: 523.88
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: PPACK, Dihydrochloride, PPACK, Dihydrochloride, CAS 82188-90-7, is an extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.
• Nivel de calidad: 100
• Ensayo: ≥80% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated; protect from light
• color: white
• solubilidad: water: 100 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C21H31ClN6O3.2ClH/c22-13-18(29)16(8-4-10-26-21(24)25)27-19(30)17-9-5-11-28(17)20(31)15(23)12-14-6-2-1-3-7-14;;/h1-3,6-7,15-17H,4-5,8-13,23H2,(H,27,30)(H4,24,25,26);2*1H/t15-,16+,17+;;/m1../s1
• Clave InChI: XKDCRQWZLPWLFG-LKLBIAKRSA-N

Descripción

Descripción general

Extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M^-1S^-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H₂O (Cat. No. 508773).

Extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M^-1S^-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin

Primary Target
Thrombin

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-D-Phe-Pro-Arg-chloromethylketone, 2HCl

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.

Otras notas

Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable