5.04042

Doxorubicin Hydrochloride

InSolution, ≥98%

• Sinónimos: InSolution Doxorubicin, Hydrochloride, Adriamycin, HCl, 14-Hydroxydaunomycin, HCl
• Fórmula empírica (notación de Hill): C₂₇H₂₉NO₁₁ · xHCl
• Número de CAS: 25316-40-9
• Peso molecular: 543.52 (free base basis)
• Número MDL: MFCD00077757
• Código UNSPSC: 12352101

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• temp. de almacenamiento: −70°C
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1
• Clave InChI: MWWSFMDVAYGXBV-FGBJBKNOSA-N

Descripción

Descripción general

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl in H₂O.

An anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC₅₀ = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Forma física

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.

Reconstitución

Following initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.

Otras notas

A′Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol.13, 726.
Nooter, K., et al. 1995. Br. J. Cancer71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany