474788

MG-132

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem^®

• Sinónimos: InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI
• Fórmula empírica (notación de Hill): C₂₆H₄₁N₃O₅
• Peso molecular: 475.62
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• product name: MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor
• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Condiciones de envío: ambient
• temp. de almacenamiento: −70°C

Descripción

Descripción general

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) is also available.

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

K_i = 4 nM for proteasomal inhibition

Reversible: yes

Secondary Target
IKK

Envase

Packaged under inert gas

Advertencia

Toxicity: Flammable (J)

Forma física

A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.

Reconstitución

Following initital thaw, aliquot and freeze (-70°C).

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H225,H319
• Consejos de prudencia: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Flam. Liq. 2
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 53.6 °F - closed cup - Information refers to the main ingredient.
• Punto de inflamabilidad (°C): 12 °C - closed cup - Information refers to the main ingredient.