420320

KT5720

≥95% (HPLC), solid, protein kinase A inhibitor, Calbiochem^®

• Sinónimos: KT5720, PKA Inhibitor VII
• Fórmula empírica (notación de Hill): C₃₂H₃₁N₃O₅
• Número de CAS: 108068-98-0
• Peso molecular: 537.61
• Número MDL: MFCD00132118
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: KT5720, A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (K_i = 56 nM) that is prepared by a chemical modification of K-252a.
• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1
• Clave InChI: ZHEHVZXPFVXKEY-RUAOOFDTSA-N

Descripción

Descripción general

A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (K_i = 56 nM) that is prepared by a chemical modification of K-252a. Does not significantly affect the activities of PKC, PKG, and MLCK. Inhibits axon branching in cultured neurons. A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420323) in DMSO is also available.

Prepared by a chemical modification of K-252a. A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (K_i = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Inhibits axon branching in cultured neurons.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
PKA

Product competes with ATP.

Reversible: yes

Target K_i: 56 nM for protein kinase A

Advertencia

Toxicity: Standard Handling (A)

Nota de preparación

Further dilute with aqueous buffers just prior to use.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Simpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci.11, 357.
Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA89, 8626.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun.142, 436.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable