116805

PKA Inhibitor 5-24

The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: PKA Inhibitor 5-24, Protein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
• Fórmula empírica (notación de Hill): C₉₄H₁₄₈N₃₂O₃₁
• Número de CAS: 99534-03-9
• Peso molecular: 2222.38
• Número MDL: MFCD00133989
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: lyophilized
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• solubilidad: water: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C94H148N32O31/c1-11-42(3)70(124-85(150)58(31-50-19-14-13-15-20-50)117-84(149)61(35-67(135)136)116-74(139)44(5)110-81(146)57(32-51-24-26-53(131)27-25-51)119-90(155)73(49(10)130)126-86(151)69(96)47(8)128)88(153)112-45(6)75(140)122-63(40-127)77(142)107-38-65(133)114-55(22-17-29-105-93(99)100)80(145)125-72(48(9)129)87(152)108-39-66(134)113-54(21-16-28-104-92(97)98)78(143)115-56(23-18-30-106-94(101)102)79(144)118-60(34-64(95)132)82(147)111-46(7)76(141)123-71(43(4)12-2)89(154)120-59(33-52-37-103-41-109-52)83(148)121-62(91(156)157)36-68(137)138/h13-15,19-20,24-27,37,41-49,54-63,69-73,127-131H,11-12,16-18,21-23,28-36,38-40,96H2,1-10H3,(H2,95,132)(H,103,109)(H,107,142)(H,108,152)(H,110,146)(H,111,147)(H,112,153)(H,113,134)(H,114,133)(H,115,143)(H,116,139)(H,117,149)(H,118,144)(H,119,155)(H,120,154)(H,121,148)(H,122,140)(H,123,141)(H,124,150)(H,125,145)(H,126,151)(H,135,136)(H,137,138)(H,156,157)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)/t42-,43-,44-,45-,46-,47?,48?,49?,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,69-,70-,71-,72-,73-/m0/s1
• Clave InChI: AXOXZJJMUVSZQY-BVDKBYOBSA-N

Descripción

Descripción general

A potent synthetic peptide that is a competitive inhibitor of protein kinase A (K_i = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.

Peptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (K_i = 2.3 nM).

Acciones bioquímicas o fisiológicas

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target K_i: 2.3 nM for protein kinase A

Envase

Yes

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH

Nota de preparación

Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization.

Otras notas

Knighton, D.R., et al. 1991. Science 253, 525.
Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
Rusine, T., et al. 1986. J. Cell Biol.102, 1630.
Wong, Y.S., et al. 1986. J. Biol. Chem..261, 12089.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable