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Documentos clave

14-685-M

Sigma-Aldrich

Cdk9/Cyclin T1 Protein, active, 10 µg

Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.

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About This Item

Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32

origen biológico

human

Nivel de calidad

recombinante

expressed in Sf9 cells

mol peso

Mw 44 kDa (cdk9)
Mw 80.79 kDa (cyclinT1)

fabricante / nombre comercial

Upstate®

técnicas

activity assay: suitable (kinase)

Nº de acceso NCBI

Nº de acceso UniProt

Información sobre el gen

human ... CDK9(1025)

Descripción general

C-terminal 6His-tagged, fulllength recombinant, human cdk9 co-expressed with untagged, full-length human cyclin T1
Product Source: expressed by baculovirus in Sf21 insect cells

Aplicación

Research Category
Inflammation & Immunology

Acciones bioquímicas o fisiológicas

Protein Target: CDK9/cyclin T1
Target Sub-Family: CMGC

Calidad

routinely evaluated by phosphorylation of PDKtide (Catalog# 12-401)

Forma física

Ni2+/NTA-agarose

Almacenamiento y estabilidad

stable for 6 months at -70°C from date of shipment

Otras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size.
Sano, Motoaki and Schneider, Michael D
Cell Cycle, 2, 99-104 (2003)
Cellular control of gene expression by T-type cyclin/CDK9 complexes.
Garriga, Judit and Gra?a, Xavier
Gene, 337, 15-23 (2004)
Li-Ying Liou et al.
The international journal of biochemistry & cell biology, 36(9), 1767-1775 (2004-06-09)
The macrophage is an important cell type in the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection. Macrophages both support viral replication and are capable of attracting and activating lymphocytes, thus rendering CD4+ T lymphocytes highly permissive for infection.
Tinggui Yin et al.
Molecular cancer therapeutics, 13(6), 1442-1456 (2014-04-02)
DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate transcriptional initiation and elongation by phosphorylating Ser 2, 5, and 7 residues on CTD. Given the reported dysregulation of

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