07-276

Anti-PDGFRα Antibody

Upstate^®, from rabbit

• Sinónimos: Anti-Anti-CD140A, Anti-Anti-PDGFR-2, Anti-Anti-PDGFR2
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, mouse
• envase: antibody small pack of 25 μL
• fabricante / nombre comercial: Upstate^®
• técnicas: immunoprecipitation (IP): suitable; western blot: suitable
• isotipo: IgG
• Nº de acceso NCBI: NM_011058
• Nº de acceso UniProt: P16234
• Condiciones de envío: ambient
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PDGFRA(5156)

Descripción

Descripción general

Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.

Especificidad

Recognizes PDGF Receptor alpha.

Inmunógeno

peptide corresponding to amino acids 1035-1053 (C-GKRNRHSSQTSEESAIETG) of human PDGF Receptor α

Aplicación

Detect PDGFRα using this Anti-PDGFRα Antibody validated for use in IP & WB.

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

Calidad

routinely evaluated by immunoblot on 3T3/NIH cell lysate

Descripción de destino

150/170 kDa (doublet)

Forma física

ImmunoAffinity Purified

Protein A Purified immunoglobulin in 0.14 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Nota de análisis

Control
HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.