P2066
Poly(D,L-lactide-co-glycolide)
lactide:glycolide 65:35, Mw 40,000-75,000
Sinónimos:
Lactel® B6001-1, PLGA
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About This Item
Fórmula lineal:
[C3H4O2]x[C2H2O2]y
Número MDL:
Código UNSPSC:
12162002
ID de la sustancia en PubChem:
NACRES:
NA.23
Productos recomendados
formulario
pellets
Nivel de calidad
cociente alimentación
lactide:glycolide 65:35
mol peso
Mw 40,000-75,000
temp. de almacenamiento
−20°C
cadena SMILES
OCC(O)=O.CC(O)C(O)=O
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Categorías relacionadas
Aplicación
- Inhaled Macrophage Apoptotic Bodies-Engineered Microparticle Enabling Construction of Pro-Regenerative Microenvironment to Fight Hypoxic Lung Injury in Mice.: This study demonstrates the use of Poly(ᴅ,ʟ-lactide-co-glycolide) (PLGA) in engineering microparticles that promote lung tissue regeneration in hypoxic conditions, highlighting its potential in developing advanced therapeutic strategies for respiratory injuries (Liu et al., 2024).
- Engineered nanoparticles promote cardiac tropism of AAV vectors.: The research explores the role of PLGA nanoparticles in enhancing the targeting efficiency of AAV vectors to cardiac tissues, showcasing its application in gene therapy and cardiovascular disease treatment (Switala et al., 2024).
- Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces.: This article reports the development of drug-loaded PLGA microparticles designed to prevent biofilm formation on oral surfaces, demonstrating the polymer′s utility in dental applications and biofilm-associated infections (Oh et al., 2024).
- Dual-layer conduit containing VEGF-A - Transfected Schwann cells promotes peripheral nerve regeneration via angiogenesis.: PLGA-based dual-layer conduits are utilized to support nerve regeneration by enhancing angiogenesis, indicating its importance in neuroregenerative medicine and peripheral nerve injury treatments (Huang et al., 2024).
- Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma.: The study highlights the dual-targeting capability of PLGA nanoparticles in delivering chemotherapy drugs to both tumor cells and the surrounding supportive stroma, emphasizing its role in advanced cancer therapies (He et al., 2024).
Características y beneficios
Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
Forma física
Biocompatible, biodegradable polymer.
Información legal
Lactel is a registered trademark of Evonik Corp
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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International journal of molecular sciences, 19(7) (2018-07-18)
Cell responses depend on the stimuli received by the surrounding extracellular environment, which provides the cues required for adhesion, orientation, proliferation, and differentiation at the micro and the nano scales. In this study, discontinuous microcones on silicon (Si) and continuous
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International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Mani Gajendiran et al.
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A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
Artículos
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
Protocolos
Preparation for biodegradable nanoparticles and their use in transfection protocols .
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