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719889

Sigma-Aldrich

Resomer® RG 502, Poli(D,L-Láctido-co-glucólido)

lactide:glycolide 50:50, ester terminated, Mw 7,000-17,000

Sinónimos:

PLGA

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About This Item

Fórmula lineal:
[C3H4O2]x[C2H2O2]y
Código UNSPSC:
12162002
NACRES:
NA.23

Nivel de calidad

200

formulario

amorphous

cociente alimentación

lactide:glycolide 50:50

mol peso

Mw 7,000-17,000

marco temporal de la degradación

<3 months

viscosidad

0.16-0.24 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

temperatura de transición

Tg 42-46 °C

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

Aplicación

Resomer® RG 502 puede utilizarse para formular un sistema de administración de nanomedicamentos basado en PLGA para el antiinflamatorio, éter de 6-bromoindirubina-3′-glicerol-oxima (6BIGOE).

También puedeutilizarse para preparar formulaciones de liberación controlada para la administración de HCl de naloxona.

Características y beneficios

  • Biocompatible
  • Biodegradable
  • Puede procesarse en casi cualquier forma y tamaño
  • Propiedades mecánicas ajustables

Información legal

Producto de Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCF8231
BCCG8280
BCCF0447
BCCD0959
BCCC4034

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Yung-Hsin Cheng et al.
Experimental eye research, 179, 179-187 (2018-11-25)
Elevated intraocular pressure (IOP) in glaucoma is due to impairment of aqueous humor drainage via the uveoscleral or trabecular outflow pathway. Latanoprost reduces IOP by increasing the uveoscleral outflow. Despite its potency, long-term daily application of it may cause undesirable
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Mani Gajendiran et al.
Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)
A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
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