N21804

3-Nitrophenylhydrazine hydrochloride

98%

• Sinónimos: (3-Nitrophenyl)hydrazine hydrochloride, 1-(3-Nitrophenyl)hydrazine hydrochloride, 3-Nitrophenylhydrazine monohydrochloride, m-Nitrophenylhydrazine hydrochloride
• Fórmula lineal: O₂NC₆H₄NHNH₂ · HCl
• Número de CAS: 636-95-3
• Peso molecular: 189.60
• Número CE: 211-270-6
• Número MDL: MFCD00012939
• Código UNSPSC: 12352100
• ID de la sustancia en PubChem: 24897354
• NACRES: NA.22

Propiedades

• Análisis: 98%
• formulario: powder
• mp: 210 °C (dec.) (lit.)
• cadena SMILES: Cl.NNc1cccc(c1)[N+]([O-])=O
• InChI: 1S/C6H7N3O2.ClH/c7-8-5-2-1-3-6(4-5)9(10)11;/h1-4,8H,7H2;1H
• Clave InChI: BKOYKMLGFFASBG-UHFFFAOYSA-N

Descripción

Descripción general

3-Nitrophenylhydrazine (3-NPH) is a derivatizing reagent used for the derivatization of carboxyl- and carbonyl-containing metabolites. This compound is also used as a high-efficiency chemical isotope-labeling reagent. Additionally, 3-nitrophenylhydrazine undergoes a condensation reaction with substituted benzaldehydes resulting in the formation of a series of ten substituted (E)-1-benzylidene-2-(3-nitrophenyl) hydrazine compounds.

Aplicación

<ul>
<li><strong>Derivatization agent in analytical chemistry:</strong> 3-Nitrophenylhydrazine hydrochloride is employed as a derivatization agent for the determination of gamma-Hydroxybutyric acid in biological samples infected with Herpes Simplex Virus-Type 1, utilizing LC-MRM-MS techniques, providing enhanced detection capabilities in forensic and clinical toxicology (Osinaga et al., 2022).</li>
<li><strong>Residual analysis in pharmaceutical formulations:</strong> This compound is also used for the quantitative analysis of residual 4-nitrobenzaldehyde in chloramphenicol and its pharmaceutical formulations, employing HPLC with UV/Vis detection after derivatization with 3-nitrophenylhydrazine, offering a reliable method for ensuring the purity and safety of pharmaceutical products (Luo et al., 2018).</li>
<li><strong>Forensic application in decomposition analysis:</strong> Used to derivatized the blood samples collected at the time of forensic autopsy (Matoba et al., 2022).</li>
</ul>

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302 + H312 + H332,H315,H319,H335
• Consejos de prudencia: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves