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Merck

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Sinónimos:
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Especie:
Human CDKN1B (1027), Mouse Cdkn1b (12576), Rat Cdkn1b (83571), chicken CDKN1B (374106), dog CDKN1B (403429), cow CDKN1B (512613), domestic cat CDKN1B (493958), chicken CDKN1B (769872), naked mole-rat Cdkn1b (101698721), domestic guinea pig Cdkn1b (100729359) ...Más
ID UniProtKB:
P46527, Q16307, Q5U0H2, Q9BUS6
ID del gen:
  • Human(1027) Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
  • Mouse(12576) cyclin-dependent kinase inhibitor 1B
  • Rat(83571) cyclin-dependent kinase inhibitor 1B
  • chicken(374106) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • dog(403429) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cow(512613) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic cat(493958) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • chicken(769872) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • naked mole-rat(101698721) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic guinea pig(100729359) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • sheep(100127219) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • Domestic Rabbit(100009037) cyclin-dependent kinase inhibitor 1B (p27, Kip1)

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
SAB4504200
Anti-phospho-p27 Kip1 (pThr198) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
WH0001027M1
Monoclonal Anti-CDKN1B antibody produced in mouse, clone 4B4-E6, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
06-996
Anti-phospho-Kip1 (Thr187) Antibody, Upstate®, from rabbit,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
06-445
Anti-Kip1 (p27) Antibody, Upstate®, from rabbit,
Reactividad de especies
human, rabbit, rat
Aplicación
immunohistochemistry
immunoprecipitation (IP)
western blot
427M-9
p27Kip1 (SX53G8) Mouse Monoclonal Antibody, ,
Reactividad de especies
human
Aplicación
immunohistochemistry

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
R7772
Roscovitine, ≥98% (TLC),
Especie
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Especie
human, rat

Proteins

Referencia del producto
Descripción
Especie
SRP5109
p27KIP1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
23-024-M
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EMU028461
MISSION® esiRNA, targeting mouse Cdkn1b,
Especie
mouse
EHU025821
MISSION® esiRNA, targeting human CDKN1B,
Especie
human