1268808

Etoposid

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethyliden-β-D-glucopyranosid), VP-16-213
• Empirische Formel (Hill-System): C₂₉H₃₂O₁₃
• CAS-Nummer: 33419-42-0
• Molekulargewicht: 588.56
• MDL-Nummer: MFCD00869325
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329749817
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• API-Familie: etoposide
• Hersteller/Markenname: USP
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26
• InChI: 1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
• InChIKey: VJJPUSNTGOMMGY-MRVIYFEKSA-N
• Angaben zum Gen: human ... TOP2A(7153) , TOP2B(7155)

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Etoposide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Etoposide Capsules
• Etoposide Injection
• Etoposide Phosphate
• Etoposide Phosphate for Injection

Biochem./physiol. Wirkung

Etopsid ist ein Antitumormittel, das Komplexe mit Topoisomerase II und DNA bildet, um die Doppelstrang- und Einzelstrangspaltung von DNA zu verstärken und die erneute Ligation reversibel zu hemmen. Blockiert den Zellzyklus in der S-Phase und G2-Phase des Zellzyklus; leitet die Apoptose in normalen und Tumorzelllinien ein; hemmt die Synthese des Onkoproteins MDM2 und leitet die Apoptose in Tumorzelllinien, die MDM2 überexprimieren ein.

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H350,H361d
• P-Sätze: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 1B - Repr. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable