SML2964

Gabexatmesylat

≥97% (HPLC)

• Synonym(e): Gabexat-Mesylat, 4-[[6-[(Aminoiminomethyl)-amino]-1-oxohexyl]-oxyl]-benzoesäure-ethylester -mesylat (Salz), FOY, Megacart
• Empirische Formel (Hill-System): C₁₆H₂₃N₃O₄ · CH₄O₃S
• CAS-Nummer: 56974-61-9
• Molekulargewicht: 417.48
• MDL-Nummer: MFCD00210299
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1
• InChI: 1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)
• InChIKey: DNTNDFLIKUKKOC-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Gabexate mesylate is a competitive inhibitor of serine proteases that displays high selectivity for TMPRSS2 (Transmembrane protease serine 2) (IC50 = 130 nM) with little or no activity towards several MMPs, caspases and USPs (>> 10 μM). Gabexate mesylate was reported to decrease inflammatory cytokines production and be useful as an anticoagulant.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable