SML1050

DC260126

≥98% (HPLC)

• Synonym(e): N-(4-Butylphenyl)-4-fluoro-benzenesulfonamide
• Empirische Formel (Hill-System): C₁₆H₁₈FNO₂S
• CAS-Nummer: 346692-04-4
• Molekulargewicht: 307.38
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• InChI: 1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3
• InChIKey: CNGHPXKWPGIDSK-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

DC260126 is a FFA1 (GPR40) selective antagonist. In FFA1-expressing CHO cells, DC260126 blocks linoleic acid-induced Ca²⁺ elevation and ERK phosphorylation (IC₅₀ = 6028 μM), as well as palmitic acid potentiated glucose-stimulated insulin secretion. The compound DC260126 blocks MIN6 β cells from palmitic acid-induced ER stress and apoptosis.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable