SML0341

Importazole

≥98% (HPLC)

• Synonym(e): N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
• Empirische Formel (Hill-System): C₂₀H₂₂N₄
• CAS-Nummer: 662163-81-7
• Molekulargewicht: 318.42
• MDL-Nummer: MFCD04077630
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825346
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: >5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4
• InChI: 1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)
• InChIKey: HKGJEZIGDHFJFL-UHFFFAOYSA-N

Beschreibung

Anwendung

Importazole has been used:

• to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
• to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
• as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
• as a functional inhibitor of Importin β in embryo treatment
• as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS

Biochem./physiol. Wirkung

Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable