Direkt zum Inhalt
Merck

SAB4200539

Sigma-Aldrich

Anti-Myocardin antibody produced in rabbit

enhanced validation

affinity isolated antibody

Synonym(e):

Anti-MYCD, Anti-MYOCD

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~107 kDa

Speziesreaktivität

rat, human, mouse

Erweiterte Validierung

recombinant expression
Learn more about Antibody Enhanced Validation

Methode(n)

immunohistochemistry: 5-10 μg/mL using human and chicken heart.
indirect immunofluorescence: 2-4 μg/mL using A10 cells.
western blot: 1.5-3.0 μg/mL using extracts of Hct116 cells

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MYOCD(93649)
mouse ... Myocd(214384)
rat ... Myocd(246297)

Allgemeine Beschreibung

Anti-Myocardin specifically recognizes human, rat and chicken myocardin (MYOCD). Myocardin is encoded by the gene mapped to human chromosome 17p11.2. It contains a conserved SAP (SAF-A/B, Acinus, and PIAS) domain, involved in the regulation of nuclear organization, chromosomal dynamics and apoptosis. The encoded protein is expressed in a precise developmentally regulated, lineage-restricted pattern in the embryo and during postnatal development.

Immunogen

a synthetic peptide corresponding to an internal sequence of human myocardin, conjugated to KLH. The corresponding sequence is identical in human myocardin isoform 2 and in rat and mouse myocardin.

Biochem./physiol. Wirkung

Myocardin (MYOCD) acts as an important smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It also plays an essential role in smooth muscle cell (SMC) differentiation. The encoded protein regulates bone morphogenetic protein 10 (BMP10) expression and is required for cardiac development, as well as cardiomyocyte survival and maintenance of heart function. MYOCD expression is associated with the development of atherosclerosis, Alzheimer′s disease and malignant transformation.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Sofie De Moudt et al.
Physiological reports, 10(18), e15410-e15410 (2022-09-20)
In vivo angiotensin II (AngII)-treatment is a widely used experimental model to induce cardiovascular disease and results in a high likelihood of abdominal aorta aneurysm (AAA) formation. This involves progressive and irreversible focal dilation of the abdominal aorta and induces
Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation.
Parmacek MS
Circulation Research, 100, 633-644 (2007)
Loss of heterozygosity: what is it good for?
Ryland GL, et al.
BMC Medical Genomics (2015)
Myocardin regulates BMP10 expression and is required for heart development
Huang J, et al.
The Journal of Clinical Investigation, 122, 3678-3691 (2012)
Jiantong Hou et al.
Experimental cell research, 382(2), 111476-111476 (2019-07-01)
The phenotypic transition of pulmonary artery smooth muscle cells (PASMCs) from a contractile/differentiated to synthetic/de-differentiated phenotype is an important mechanism for the occurrence and development of hypoxic pulmonary hypertension (HPH). Integrin-linked kinase (ILK) is an early hypoxic response factor whose

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.