A9522
Anti-Antithrombin III antibody produced in rabbit
fractionated antiserum, lyophilized powder
Synonym(e):
Anti-AT3
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About This Item
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
fractionated antiserum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
lyophilized powder
Speziesreaktivität
human
Verpackung
vial of 2 mL lyophilized antiserum
Methode(n)
indirect ELISA: 1:25,000
UniProt-Hinterlegungsnummer
Lagertemp.
2-8°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... SERPINC1(462)
Allgemeine Beschreibung
Antithrombin III (ATIII) is a small glycoprotein produced by the liver that functions as a serine protease inhibitor to block coagulation.
Antithrombin III is a 58kDa glycoprotein synthesized in the liver. It has two domains, a heparin-binding domain and target protease binding domain.
Immunogen
human antithrombin III
Anwendung
Anti-Antithrombin III antibody has been used in western blotting and antigenic assay.
Biochem./physiol. Wirkung
Antithrombin III is a serine protease inhibitor which affects many intrinsic and extrinsic blood coagulation pathways. It inactivates the function of thrombin and factor X in blood. Severe sepsis is caused due to lack of antithrombin III.
Physikalische Form
Lyophilized from 0.01 M phosphate buffered saline, pH 7.2
Rekonstituierung
Reconstitute with 2 mL deionized water.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Eye Dam. 1
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Defects of splicing in antithrombin deficiency
de la Morena-Barrio M E, et al.
Research and practice in thrombosis and haemostasis, 1(2), 216-222 (2017)
Mara Toderici et al.
PloS one, 11(3), e0152159-e0152159 (2016-03-24)
Antithrombin is a crucial anticoagulant serpin whose even moderate deficiency significantly increases the risk of thrombosis. Most cases with antithrombin deficiency carried genetic defects affecting exons or flanking regions of SERPINC1.We aimed to identify regulatory mutations inSERPINC1 through sequencing the
Antithrombin III in patients with severe sepsis
Eisele B, et al.
Intensive Care Medicine, 24(7), 663-672 (1998)
María Eugenia de la Morena-Barrio et al.
Frontiers in cardiovascular medicine, 9, 887664-887664 (2022-08-09)
Aortic valve replacement is the gold standard treatment for severe symptomatic aortic stenosis, but thrombosis of bioprosthetic valves (PVT) remains a concern. To analyze the factors involved in the contact pathway during aortic valve replacement and to assess their impact
Carlos Bravo-Pérez et al.
JCI insight, 7(19) (2022-10-11)
Antithrombin, a major endogenous anticoagulant, is a serine protease inhibitor (serpin). We characterized the biological and clinical impact of variants involving C-terminal antithrombin. We performed comprehensive molecular, cellular, and clinical characterization of patients with C-terminal antithrombin variants from a cohort
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
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