SAB4200180

Anti-Cullin 3 antibody ,Mouse monoclonal

clone CUL3-9, purified from hybridoma cell culture

• Synonym(e): Anti-CUL3
• MDL-Nummer: MFCD03454920
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified from hybridoma cell culture
• Antikörper-Produkttyp: primary antibodies
• Klon: CUL3-9, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 80 kDa
• Speziesreaktivität: rat, human, mouse
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): suitable; western blot: 0.5-1.0 μg/mL using whole extracts of human Jurkat cells or mouse brain.
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: Q13618
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CUL3(8452) ; mouse ... Cul3(26554) ; rat ... Cul3(301555)

Beschreibung

Allgemeine Beschreibung

Cullin 3 (CUL3) is a member of cullin protein family and is encoded by the gene mapped to human chromosome 2q36.2. The encoded protein is a core component of cullin/RING E3 ubiquitin ligase (CRL) and is ubiquitously expressed. The protein is characterized with a cullin homology domain.

Monoclonal Anti-Cullin 3 (mouse IgG1 isotype) is derived from the hybridoma CUL3-9 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide of human Cullin 3.

Anwendung

Monoclonal Anti-Cullin 3 antibody produced in mouse has been used in western blotting and immunoprecipitation.

Biochem./physiol. Wirkung

Cullin 3 (CUL3) acts as a scaffold protein and facilitates the organization of a large number of ubiquitin ligase complexes. It plays a vital role in the regulation of electrolyte homeostasis and blood pressure. The encoded protein acts as a key factor in protein ubiquitination and is also implicated in early embryonic development. One important role of CUL3 is to promote invasion and migration of trophoblast cells. Mutation in the gene leads to onset of pre-eclampsia and pseudohypoaldosteronism type II.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable