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Merck

S4197

Sigma-Aldrich

Anti-Sirt6 (C-terminal) in Kaninchen hergestellte Antikörper

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-NAD-dependent deacetylase sirtuin 6, Anti-SIR2-like protein 6, Anti-SIR2L6

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~40 kDa

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

indirect immunofluorescence: suitable
western blot: 0.5-1 μg/mL using whole extracts of human U87 cells
western blot: 2.5-5 μg/mL using human HeLa cells

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... SIRT6(51548)

Allgemeine Beschreibung

Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.

Immunogen

synthetic peptide corresponding to amino acids 330-348 of human Sirt6.

Anwendung

Anti-Sirt6 (C-terminal) antibody has been used in
  • immunoblotting
  • immunofluorescence
  • western blotting
  • immunohistochemistry

Biochem./physiol. Wirkung

Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD+ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

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Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment
Balestrieri M L, et al.
Diabetes, 64(4), 1395-1406 (2015)
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
Mao Z, et al.
Proceedings of the National Academy of Sciences of the USA, 109(29), 11800-11805 (2012)
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
Lappas, Martha
Mediators of Inflammation, 2012 (2012)
Longsen Han et al.
Scientific reports, 5, 15366-15366 (2015-10-21)
Sirt6, a member of the sirtuin family of NAD-dependent protein deacetylases, has been implicated in multiple biological processes. However, the roles of Sirt6 in meiosis have not been addressed. In the present study, by employing knockdown analysis in mouse oocytes
Juan Ge et al.
Aging, 11(7), 1965-1976 (2019-03-31)
It has been well recognized that oocyte quality declines in aging animals. However, to date, the underlying mechanism remains to be explored. In the present study, we report that oocytes and embryos from aged mice (42-45 weeks old) display the

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