S0758

Sulfaphenazole

≥98%

• Synonym(e): 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
• Empirische Formel (Hill-System): C₁₅H₁₄N₄O₂S
• CAS-Nummer: 526-08-9
• Molekulargewicht: 314.36
• EG-Nummer: 208-384-3
• MDL-Nummer: MFCD00057226
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 24278198
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98%
• Form: powder
• Löslichkeit: ethanol: 25 mg/mL, clear, colorless to yellow
• Lagertemp.: 2-8°C
• SMILES String: Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3
• InChI: 1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
• InChIKey: QWCJHSGMANYXCW-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP2C18(1562) , CYP2C19(1557) , CYP2C9(1559)

Beschreibung

Anwendung

Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition. It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells and microsomal preparations.

Biochem./physiol. Wirkung

Antibacterial. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Inhibits bradykinin-induced tPA release.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)