B8686

(+)-N-3-Benzyl Nirvanol

≥98% (HPLC), powder, CYP2C19 inhibitor

• Synonym(e): 5-ethyl-5-phenyl-3-(phenylmethyl)-2,4-imidazolidinedione, 5-ethyl-5-phenyl-3-(phenylmethyl)-hydantoin
• Empirische Formel (Hill-System): C₁₈H₁₈N₂O₂
• CAS-Nummer: 790676-40-3
• Molekulargewicht: 294.35
• MDL-Nummer: MFCD09840024
• UNSPSC-Code: 12161501
• PubChem Substanz-ID: 329773138
• NACRES: NA.77

Eigenschaften

• product name: (+)-N-3-Benzyl Nirvanol, ≥98% (HPLC), powder
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: DMSO: >20 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: CC[C@]1(NC(=O)N(Cc2ccccc2)C1=O)c3ccccc3
• InChI: 1S/C18H18N2O2/c1-2-18(15-11-7-4-8-12-15)16(21)20(17(22)19-18)13-14-9-5-3-6-10-14/h3-12H,2,13H2,1H3,(H,19,22)/t18-/m0/s1
• InChIKey: ZMZDHUHMXXALFX-SFHVURJKSA-N

Beschreibung

Anwendung

(+)-N-3-Benzylnirvanol may be used as a cytochrome P450 2C19 (CYP2C19) inhibitor in a comparison study to treat cocktail and individual substrates for the screening for potent cytochrome P450 (CYP) inhibition. It may also be used in comparative studies to investigate its potential as CYP and non-CYP selective inhibitors of CYP2C19 in suspended human hepatocytes.

Biochem./physiol. Wirkung

(+)-N-3-Benzyl-nirvanol is a potent selective CYP2C19 inhibitor. CYP2C19 has a high frequency of drug resistance; highly polymorphic.

(+)-N-3-Benzylnirvanol serves as an inhibitor of cytochrome P450 2B6 (CYP2B6).

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H319,H400
• P-Sätze: P264 - P270 - P273 - P280 - P301 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves