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P9386

Sigma-Aldrich

Poly-L-Histidin

mol wt 5,000-25,000

Synonym(e):

L-Histidine homopolymer

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About This Item

CAS-Nummer:
26062-48-6
MDL-Nummer:
MFCD00166382
UNSPSC-Code:
12352209
PubChem Substanz-ID:
24899031
NACRES:
NA.26

Form

powder or solid

Qualitätsniveau

200

Mol-Gew.

5,000-25,000

Farbe

white to light yellow

Anwendung(en)

cell analysis

Lagertemp.

−20°C

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChIKey

HNDVDQJCIGZPNO-YFKPBYRVSA-N

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Allgemeine Beschreibung

Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.

Anwendung

Poly-L-histidine has been used:
  • as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
  • as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
  • in screening its anti-prion activity in cell based and in vivo anti-prion assay

Biochem./physiol. Wirkung

Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.

Hinweis zur Analyse

Molecular weight by MALLS.

Sonstige Hinweise

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Hongbo Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1935-1944 (2012-07-12)
Many laboratories use recombinant UDP-glucuronosyltransferases (UGTs), expressed in baculovirus-infected insect cells, for drug glucuronidation studies. We have infected Sf9 insect cells with increasing amounts of recombinant baculovirus, encoding either UGT1A9 or UGT2B7, and measured both glucuronidation activity and immunodetectable UGT
Pablo R Dalmasso et al.
Biosensors & bioelectronics, 39(1), 76-81 (2012-07-17)
We report for the first time the development of a sensitive and selective glucose biosensor based on the self-assembling of multiwall carbon nanotubes (MWCNTs) dispersed in polyhistidine (Polyhis) and glucose oxidase (GOx) on glassy carbon electrodes (GCE). The supramolecular architecture
Shoichiro Asayama et al.
Bioconjugate chemistry, 23(7), 1437-1442 (2012-06-12)
Poly(L-histidine) (PLH) with dimethylimidazole groups has been synthesized as a pH-sensitive polypeptide to control the stability of its small interfering RNA (siRNA) polyion complexes for RNA interference (RNAi). The resulting methylated PLH (PLH-Me) was water-soluble despite deprotonation of the imidazole
Poly (l-histidine) based copolymers: effect of the chemically substituted l-histidine on the physio-chemical properties of the micelles and in vivo biodistribution
Zhang X, et al.
Colloids and Surfaces. B, Biointerfaces, 140(5), 176-184 (2016)
Yi-Fang Zeng et al.
Biomaterials, 33(36), 9239-9245 (2012-10-03)
Loading of viral vectors in synthetic polymers is a promising strategy for overcoming hurdles associated with viral gene delivery. For enhanced gene expression at a specific site, gene transfer by using hydrogels represents a versatile approach. In this study, adeno-associated
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