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P3134
Phosphodiesterase I aus Crotalus adamanteus Gift
Type VI, crude dried venom
Synonym(e):
5′-Exonuclease, Oligonucleat-5′-Nucleotidohydrolase
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Allgemeine Beschreibung
Research area: Cell signaling. PhosphodiesteraseI (PDEI) exists in three isoforms PDE1A, PDE1B, and PDE1C(2) are localized to the central nervous system, cardiovascular, and other organs.
Anwendung
Phosphodiesterase I from Crotalus adamanteus venom has been used:
- for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
- as a model for the hydrolysis of prodrugs in phosphodiesterase assay
- as a component in the nucleotide cleavage buffer
Biochem./physiol. Wirkung
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. PhosphodiesteraseI (PDEI) can hydrolyze 3′,5′-cyclic adenosine monophosphate (cAMP) and3′,5′-cyclic guanosine monophosphate (cGMP). It binds to Ca2+/calmodulin(CaM) that lead to the stimulation of its catalytic activity.PDEIacts as a biotherapeutic for the treatment of cancer, heart diseases,pulmonary, metabolic, neurocognitive, renal, endocrine abnormalities, andneurological disorders.
Inhibitor
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Beschreibung
Preisangaben
Substrat
Produkt-Nr.
Beschreibung
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Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Resp. Sens. 1
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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