P0042

PP2

≥98% (HPLC)

• Synonym(e): 4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, AG 1879
• Empirische Formel (Hill-System): C₁₅H₁₆ClN₅
• CAS-Nummer: 172889-27-9
• Molekulargewicht: 301.77
• MDL-Nummer: MFCD01568210
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329819994
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
• InChI: 1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
• InChIKey: PBBRWFOVCUAONR-UHFFFAOYSA-N

Beschreibung

Anwendung

PP2 has been used:

• to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance
• for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells
• for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells

Biochem./physiol. Wirkung

PP2 is a selective inhibitor of Src-family tyrosine kinases of non-receptor tyrosine kinases (nRTK). It shows >10,000-fold selectivity over Zeta-chain-associated protein kinase 70 (ZAP-70) and Janus kinase 2 (JAK2). PP2 effectively reduces cervical cancer proliferation in vitro and in vivo.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable