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N3376

Sigma-Aldrich

Nicotinamid

≥98% (HPLC), powder, PARP inhibitor

Synonym(e):

Niacinamid, Nicotinsäureamid, Pyridin-3-carbonsäureamid, Vitamin B3, Vitamin PP

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About This Item

Empirische Formel (Hill-System):
C6H6N2O
CAS-Nummer:
98-92-0
Molekulargewicht:
122.12
Beilstein:
383619
EG-Nummer:
202-713-4
MDL-Nummer:
MFCD00006395
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24897638
NACRES:
NA.77

product name

Nicotinamid, ≥98% (HPLC), powder

Qualitätsniveau

200

Assay

≥98% (HPLC)

Form

powder

Farbe

white

mp (Schmelzpunkt)

128-131 °C (lit.)

Anwendung(en)

cell analysis

SMILES String

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Angaben zum Gen

human ... PARP1(142) , SIRT2(22933)

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Verwandte Kategorien

Anwendung

Used as a cofactor for certain enzymes

Biochem./physiol. Wirkung

Nicotinamid ist ein Amid-Derivat von Vitamin B3 und ein PARP-Inhibitor.

Leistungsmerkmale und Vorteile

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Lagerung und Haltbarkeit

This product can be stored tightly closed in room temperature and in dry conditions.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319

Gefahreneinstufungen

Eye Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

302.0 °F - closed cup

Flammpunkt (°C)

150 °C - closed cup

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Niacinamid meets USP testing specifications

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Sigma-Aldrich

A9165

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A 83-01 ≥98% (HPLC)

Sigma-Aldrich

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ββ-Nicotinamid-Mononukleotid ≥95% (HPLC)

Sigma-Aldrich

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Christian W Johnson et al.
Cell reports, 28(6), 1538-1550 (2019-08-08)
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or
Ann-Lii Cheng et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(32), 4067-4075 (2013-10-02)
Open-label, phase III trial evaluating whether sunitinib was superior or equivalent to sorafenib in hepatocellular cancer. Patients were stratified and randomly assigned to receive sunitinib 37.5 mg once per day or sorafenib 400 mg twice per day. Primary end point
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality
Kathrin Schmeisser et al.
Nature chemical biology, 9(11), 693-700 (2013-10-01)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans lifespan. Sirtuins mandatorily convert NAD(+)
Thomas J Herzog et al.
Gynecologic oncology, 130(1), 25-30 (2013-04-18)
Sorafenib, an oral multikinase inhibitor of the VEGFR/PDGFR/Raf/MEK/ERK pathway, has shown potential activity in patients with recurrent ovarian cancer (OC). One strategy to prolong disease control and survival in patients with OC is maintenance therapy after achieving a complete response.
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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.