M4531

Meclofenamic acid sodium salt

• Synonym(e): 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt
• Lineare Formel: C₁₄H₁₀Cl₂NO₂Na
• CAS-Nummer: 6385-02-0
• Molekulargewicht: 318.13
• EG-Nummer: 228-983-3
• MDL-Nummer: MFCD00077376
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24278553
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 100
• Assay: ≥93% (HPLC)
• Form: powder
• Löslichkeit: water: 50 mg/mL, clear, colorless to faintly brownish-yellow; water: 50 mg/mL, clear, colorless to faintly yellow; water: 50 mg/mL, clear, colorless to very faintly brown
• SMILES String: [Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
• InChI: 1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
• InChIKey: CHGIZYUDGOIAFY-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Meclofenamic acid consists of two aryl moieties that are twisted in perpendicular orientation, it includes N-2,6-dichloro-3-methylphenyl group and N-2-benzoic acid group. Because of the low aqueous solubility of the compound, it is commercially available as sodium salt.

Anwendung

Meclofenamic acid sodium salt has been used:

• in the inhibition of heat-induced denaturation of albumin
• as a pharmacological agent in the preparation of superfusion solution for electrophysiology studies
• to block the gap junctions

Biochem./physiol. Wirkung

Cyclooxygenase (IC₅₀ = 0.6 μM) and 5-lipoxygenase (IC₅₀ = 46.3 μM) inhibitor.

Meclofenamic acid (MFA) is a nonsteroidal anti-inflammatory, analgesic and antipyretic drug. It inhibits prostaglandin biosynthesis pathway and finds its application in the treatment of postoperative and traumatic inflammation and swelling. MFA functions in opening the potassium voltage-gated channel subfamily Q member 2/member 3 (KCNQ2/Q3).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)